Table 9.
Anti-malarial drug treatment and outcome
|
Variable |
All |
Alive |
Died |
|||
|---|---|---|---|---|---|---|
| +/− | % | +/− | % | +/− | % | |
| Non-artemisinin/artemisinin derivative therapy |
580/378 |
60.5 |
521/362 |
59.0 |
59/16 |
78.7 |
| Parenteral quinine/artemisinin derivative. Patients given both parenteral quinine and artemisinin derivatives excluded |
430/276 |
60.9 |
371/261 |
58.7 |
59/15 |
79.7 |
| Oral quinine/artemisinin derivative and no parenteral anti-malarial |
93/60 |
60.8 |
93/60 |
60.8 |
0/0 |
- |
| Number given/not given antibiotic a |
124/818 |
13.2 |
94/778 |
10.8 |
30/40 |
42.9 |
| No. given/not given inotrope |
65/872 |
6.9 |
13/856 |
1.5 |
52/16 |
76.5 |
| No. given/not given anti-epileptic drug |
97/843 |
10.3 |
59/812 |
6.8 |
38/31 |
55.1 |
| No. given/not given nasogastric tube |
65/859 |
7.0 |
36/828 |
4.2 |
29/31 |
48.3 |
| No. given/not given urinary catheter |
207/728 |
22.1 |
142/725 |
16.4 |
65/3 |
95.6 |
| No. given/not given blood transfusion |
160/828 |
16.2 |
132/779 |
14.5 |
28/49 |
36.4 |
| No. given/not given dialysis |
31/898 |
3.3 |
7/854 |
0.8 |
24/44 |
77.4 |
| No. given/not given ventilation |
85/845 |
9.1 |
25/839 |
2.9 |
60/6 |
90.9 |
| No. given/not given central venous access line |
99/840 |
10.5 |
45/825 |
5.2 |
54/15 |
78.3 |
| No. given/not given lumbar puncture |
90/849 |
9.6 |
56/813 |
6.4 |
34/36 |
48.6 |
| No. developing/not developing pulmonary oedema |
14/958 |
1.4 |
7/888 |
0.8 |
7/70 |
9.1 |
| No. developing/not developing oliguria |
94/843 |
10.0 |
43/826 |
5.0 |
51/17 |
75.0 |
| No. developing/not developing seizures |
39/909 |
4.1 |
20/852 |
2.3 |
19/57 |
25.0 |
| No. of nights in hospitalb |
4 (1–34) |
- |
4 (1–34) |
- |
2 (1–27) |
- |
| Coma Recovery Time/hb |
24 (1–188) |
- |
- |
- |
- |
- |
| Time to death/hb | - | - | - | - | 44 (2–641) | - |
a excluding doxycycline and tetracycline given for malaria. b Median (range). All comparisons between alive and dead were statistically significant (P < 0.001, adjusted for study site).