Table 3.
Univariate analysis of survival
| Variable | Cases | Median survival (months) | 95% CI (months) | P value |
|---|---|---|---|---|
| Age (years) | 0.867 | |||
| <55 | 28 | 14.7 | 5.0–24.4 | |
| ≥55 | 21 | 14.5 | 12.0–17.0 | |
| Gender | 0.182 | |||
| Male | 37 | 19.2 | 10.5–28.0 | |
| Female | 12 | 12.1 | 8.2–16.0 | |
| Histology | 0.244 | |||
| Adenocarcinoma | 42 | 14.6 | 4.7–24.6 | |
| Nonadenocarcinoma | 7 | 13.2 | 12.3–14.2 | |
| RPA | <0.001 | |||
| I | 13 | 33.5 | 15.9–51.1 | |
| II | 29 | 14.5 | 12.5–16.5 | |
| III | 7 | 3.7 | 2.6–4.8 | |
| Number of brain metastases | 0.081 | |||
| 1 | 36 | 20.1 | 10.3–30.0 | |
| ≥2 | 13 | 12.1 | 7.1–17.2 | |
| Primary tumor | <0.001 | |||
| Controlled | 36 | 22.0 | 12.2–31.8 | |
| Uncontrolled | 13 | 9.3 | 4.0–9.9 | |
| Treatment modality | <0.001 | |||
| Craniotomy + WBRT | 41 | 20.1 | 11.6–28.7 | |
| Craniotomy only | 8 | 3.2 | 0.5–6.0 | |
| B7-H4 expression | 0.002 | |||
| Low | 29 | 26.2 | 10.2–42.3 | |
| High | 20 | 11.4 | 5.8–16.9 |
Abbreviations: CI, confidence interval; RPA, recursive partitioning analysis; WBRT, whole-brain radiotherapy.