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. 2013 Jul 15;8(7):e68300. doi: 10.1371/journal.pone.0068300

Figure 5. The presence of α5α4* nAChR does not affect ethanol-mediated potentiation of ACh-induced nicotinic current.

Figure 5

(A) The amplitude of a 300 ms ACh-induced sample current trace elicited every 2 min during a 10 min exposure to ethanol (80 mM) is increased from baseline in neurons from α5+/+ (black) and α5-/- (gray) mice. (B) The time course of the potentiation of current from baseline for a 10 min exposure of 80mM ethanol in α5+/+ and α5-/- mice. (C) The average percent of baseline current after 10 min of 60 mM and 80 mM ethanol exposure for α5+/+ and α5-/- mice. In B&C, n= 5-10 cells across 5-8 animals. The values in B&C are reported as mean percent of baseline ± SEM (two-way ANOVA followed by Neuman-Keuls post hoc test). The calibrations for the current trace are 25 pA, 0.5 sec.