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. 2013 Jun 14;62(7):2588–2594. doi: 10.2337/db12-1822

FIG. 4.

FIG. 4.

Percentage wound closure of cutaneous ulcers 1 week after treatment with MSCs seeded in a collagen scaffold. Analysis between groups using ANOVA and Fisher pairwise comparison. *P < 0.05. Error bars = SD. MSCs (1,000,000) seeded on a collagen scaffold result in a significantly increased percentage of wound closure as compared with control. There was no observed difference in the observed percentage wound closure between the other treatment groups, i.e., collagen + 50,000 MSCs, collagen + 100,000 MSCs, or collagen alone, when compared with untreated wounds. This result supports the hypothesis that the wound healing effect of MSC and collagen treatment occurs in a dose-dependent fashion. Increased cell doses increase the percentage wound closure and rate of wound healing. (A high-quality color representation of this figure is available in the online issue.)