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. 2013 Jun 14;62(7):2249–2258. doi: 10.2337/db12-1146

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© 2013 by the American Diabetes Association.

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FIG. 6. — Hepatic lipid metabolism during fasting and refeeding from NT and hGLUT4 TG mice fed CD or HFD for 8 weeks. Livers were removed from mice fasted for 17 h (Fasted) or fasted mice refed for 4 h (Refed) after 8 weeks on the diet. Hepatic mRNA was isolated and analyzed for SREBP-1c mRNA (A) and FAS mRNA (B) (four independent experiments). Lipid-soluble material was isolated from blood plasma (n = 5 per group) (C) and liver homogenates (D) and assayed for total TAG level (n = 5 per group). Statistical differences between fasted and refed mice are indicated. *Significant difference in refed mice between strains and diets, ¶significant difference in fasted animals when comparing both strains and diets, #significant difference in fasted animals when comparing the same diet in different strains, and †significant difference in refed animals when comparing the same strain. NS, not significant.