Skip to main content
. 2013 Jun 14;62(7):2215–2222. doi: 10.2337/db12-1523

FIG. 1.

FIG. 1.

Blood glucose responses to repeated insulin-induced hypoglycemia. Antecedent hypoglycemia was induced by subcutaneous insulin injection (10 units/kg) and variable rate glucose infusion over a 3-day conditioning period in all rats (n = 19) (A). The next day (Expt-D1), rats were randomly allocated to either the control group (n = 7) (B) or the SSTR2a treatment group (n = 12) (C) for baseline assessment of counterregulatory responses by using a combination of insulin bolus (10 units/kg i.v.) and infusion (50 mU/kg/min i.v.) at the discretion of the investigator until moderate hypoglycemia ensued (target 3.0 mmol/L) (B). One day later, on Expt-D2, the insulin infusion treatment protocol was duplicated for each rat, either with (SSTR2a group) or without (controls) SSTR2a infusion (3,000 nmol/kg/min i.v.), which commenced 60 min prior to insulin treatment. Values are means ± SEM.

HHS Vulnerability Disclosure