FIG. 1.

GLUT4 expression in adipocytes of PCOS patients. A: GLUT4 mRNA expression was significantly reduced in primary subcutaneous (sc) adipocyte culture derived from PCOS patients (n = 21) compared with matched control (CRL) subjects (n = 20). B: GLUT4 protein was also reduced in PCOS. C: Taking IR into account, significant differences are observed in GLUT4 expression between IR and non-IR groups in primary adipocyte culture. D: In whole AT, GLUT4 is significantly lower in PCOS and further reduced if the patient demonstrated IR. E: In ATs from all patients studied, GLUT4 gene expression was negatively correlated to HOMA-IR (r = −0.57, n = 25, P < 0.002). All data are shown as means ± SEM (error bars). *P < 0.05; **P < 0.01.