Figure 1.

Over a period of 10 days, a MDA-MB-231 model of breast cancer was established in mice, after which eight intraperitoneal injections of Chalone 19-peptide 6.6 mg/kg and cyclophosphamide 50 mg/kg or 100 mg/kg were given. The mice were sacrificed 28 days after the final injection. Photographs showing mice from the (A) Cyclophosphamide 100 mg/kg group, (B) Chalone 19-peptide 6.6 mg/kg group, (C) cyclophosphamide 100 mg/kg and Chalone 19-peptide 6.6 mg/kg group, (D) cyclophosphamide 50 mg/kg and Chalone 19-peptide 6.6 mg/kg group, and (E) control group. (F) Relationship between tumor formation time and volume, showing that mean tumor size was smaller in the active treatment groups than in controls (P < 0.05). (G) Relationship between tumor formation time and weight in tumor-bearing nude mice.

Abbreviation: CTX, cyclophosphamide.