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Schematic illustration of two alternative mechanisms of activation of MYB in fusion-negative adenoid cystic carcinomas, that is insertions of a segment from 9p23–p22. 3, including the 3′-part of NFIB, immediately centromeric to the MYB locus or t(6;9) translocations with breakpoints 10–100 kb distal to MYB. In both cases, the proximity of the 3′-part of NFIB and its flanking sequences to MYB leads to transcriptional activation of an apparently intact MYB gene
