Figure 4.

Phosphorylation sites and subsequent protein interactions of the syndecan cytoplasmic domains. Serine and tyrosine residue phosphorylation by kinases and phosphatases are depicted for each syndecan, together with the consequential binding of effector proteins. Interactions are classified as direct (solid lines) and indirect (dotted lines) with those that bind via a PDZ domain shown with pink lines. Residue numbers correspond to the human sequences; asterisks indicate active protein forms. Although some of the interactions have not been empirically determined, those that have been reported are tabulated in supplementary Table S3.