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. 2010 Sep;43(5):433–439. doi: 10.1016/j.jelectrocard.2010.05.015

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© 2010 Elsevier Inc.

Open Access under CC BY 3.0 license

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Fig. 3 — A-D, Traces from chest leads (A, C) and limb leads (B, D) of a Scn5a+/− heart showing minor ST elevation before flecainide (A) and accentuated ST elevation after flecainide (C) in the chest leads but no appreciable ST elevation in the limb leads either before (B) or after (D) addition of flecainide. E and F, ST elevation measured from chest and limb leads for WT (E) and Scn5a+/− (F) hearts before and after the addition of flecainide or quinidine. Ten WT and ten Scn5a+/− hearts were used, with 5 of each exposed to each drug. Results from chest leads are denoted by solid symbols; results from limb leads are denoted by open symbols. ^†Results of t tests comparing WT and Scn5a+/− hearts giving values indicating significance. ^⁎Results of t tests comparing values before and after drug in the same hearts giving values indicating significance. ^#Results of t tests comparing values between chest and limb leads in the same hearts giving values indicating significance.