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. 2013 Jul 16;4:200. doi: 10.3389/fimmu.2013.00200

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Copyright © 2013 Horton and Vidarsson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Antigen sampling and amplification of humoral immune responses. (A) SIgA recognizing its cognate antigen (1) is taken up by M cell, possibly though a yet unidentified receptor on M cells. This complex has been demonstrated to traverse the epithelial layer (2) and to be taken up by DCs (3) possibly through DC-SIGN recognition. (B) Similarly, antigen bound by IgG (1) can traverse the epithelial layer through FcRn-depended transcytosis and taken up by DCs through FcγR and FcRn (2) (73). Both IgG- or IgA-mediated antigen uptake can enhance antigen presentation, subsequent activation and proliferation of antigen-specific B- and T cells, boosting immune responses (3). See text for more details.