Figure 1.
Combined association results for the extended HLA region (chromosome 6, 26–34 Mb). SNPs with P < 0.001 in the overall joint analysis are represented, color-coded by odds ratio (OR) strata. SNPs of interest include (i) rs3131379 (position 31.829012 Mb, gene MSH5; OR = 2.36, P = 1.7 × 10−52); (ii) rs1270942 (position 32.026839 Mb, gene RDBP; OR 2.35, 32.369230 = P = 1.3 × 10−51); (iii) rs7775397 (position 32.369230 Mb, gene C6orf10; OR = 2.28, P = 8.0 × 10−47); (iv) rs9275572 (position 32.786977 Mb, no gene known; OR = 1.69, P = 7.0 × 10−48); (v) rs1794282 (position 32.774504 Mb, no gene known; OR = 2.26, P = 2.6 × 10−46) and (vi) rs7192 (position 32.519624 Mb, gene HLA-DRA; OR = 1.61, P = 6.2 × 10−40).