Table 2.
Stepwise logistic regression model of the independent genetic contributions of the associated markers to SLE risk
Gene | SNP | Chromosome | OR | 95% CI | P |
---|---|---|---|---|---|
PXK | rs6445975 | 3p14.3 | 1.27 | 1.15–1.39 | 9.2E-07 |
HLA region | rs3131379 | 6p21.33 | 1.82 | 1.58–2.09 | 4.5E-17 |
HLA region | rs9275572 | 6p21.32 | 1.40 | 1.27–1.54 | 2.8E-12 |
IRF5/TNPO3 | rs12537284 | 7q32.1 | 1.61 | 1.42–1.81 | 1.7E-14 |
KIAA1542 | rs4963128 | 11p15.5 | 0.78 | 0.71–0.85 | 1.3E-07 |
ITGAM | rs9888739 | 16p11.2 | 1.70 | 1.51–1.92 | 1.9E-18 |
| |||||
C statistic | 0.67 |
Data used for logistic regression are from the 210 SNPs available from Sets 1–4. Entry or removal from the model at each step required P < 10−6. Abbreviations are the same as in Table 1.