Skip to main content
. Author manuscript; available in PMC: 2013 Jul 16.
Published in final edited form as: J Heart Lung Transplant. 2009 Apr;28(4):373–379. doi: 10.1016/j.healun.2009.01.016

Table 3.

Associations of polymorphisms in RAAS genes with disease severity (as assessed by hemodynamic parameters obtained by right heart catheterization). Categories of PAH include IPAH, PAH/CTD, PAH anorexigen exposure, and all 3 categories of PAH analyzed collectively. Values listed are mean +/− standard deviation with the number of subjects indicated in parentheses. None of the associations remained significant after correction for multiple testing.

Phenotype Disease Gene Genotypes p
ACE DD DI II
Mixed venous oxygen saturation (%) PAH/CTD 63 +/− 9 (15) 53 +/− 11 (17) 65 +/− 8 (10) 0.04
Systemic arterial oxygen saturation (%) PAH/CTD 94 +/− 3 (15) 90 +/− 6 (17) 94 +/− 5 (10) 0.01
Mixed venous oxygen saturation (%) All PAH 62 +/− 10 (72) 59 +/− 11 (81) 64 +/− 10 (42) 0.05
AGT T/T T/C C/C
SAPm (mmHg) IPAH 80 +/− 14 (47) 84 +/− 14 (67) 77 +/− 16 (39) 0.03
Systemic arterial oxygen saturation (%) PAH/CTD 89 +/− 6 (8) 92 +/− 5 (24) 95 +/− 3 (9) 0.04
Pulmonary vascular resistance index (U · m2) PAH/CTD 29 +/− 13 (6) 16 +/− 8 (21) 26 +/− 19 (9) 0.03
CMA1 A/A A/G G/G
Cardiac index (l/min/m2) All PAH 2.5 +/− 1.3 (21) 3.2 +/− 1.6 (34) 2.4 +/− 0.9 (26) 0.03
IPAH 2.4 +/− 1.2 (24) 3.2 +/− 1.6 (36) 2.4 +/− 0.9 (26) 0.02
IPAH/anorexigens 2.4 +/− 1.2 (35) 2.9 +/− 1.4 (50) 2.3 +/− 0.9 (42) 0.03
AGTR1 A/A A/C C/C
SAPm (mmHg) IPAH 80 +/− 15 (86) 82 +/− 14 (60) 95 +/− 10 (5) 0.04