Table 2.
Model pharmacokinetic parameter estimates for i.m. dexamethasone
| Parameter | Definition | Estimate | SE % |
|---|---|---|---|
| CLHealthy (l/h/kg) | Clearance in healthy Lewis rats | 1.05 | 4.08 |
| CLArthritic (l/h/kg) | Clearance in arthritic Lewis rats | 1.19 | 3.00 |
| CLD (l/h/kg) | Distributional clearance | 7.20 | 42.5 |
| VP (l/kg) | Central volume of distribution | 3.41 | 2.83 |
| VSS (l/kg) | Steady-state volume of distribution | 4.85 | 3.17 |
| ka (1/h) | Intramuscular absorption rate constant | 5.78 | 10.0 |
| η CL | Interanimal variation of clearance | 0.0565 | 45.0 |
| CCV | Slope of random error | 0.215 | 18.3 |