Table 2.

Pharmacodynamic parameters for MPL effects on body weights

Parameter	Definition (doses)	Estimate	CV%
$k_{\mathrm{d}}^{\text{Bwt}}\left({\mathrm{h}}^{-1}\right)$	Weight loss rate constant	0.0033	10
$S_{\text{max}}^{\text{Bwt}}$	Maximal stimulation	1.04	9
${\mathit{SC}}_{50}^{\text{Bwt}}(\text{ng}∕\text{ml})$	Stimulation constant	16.4	17
%Bwtss (%)	Maximal weight	100	Fixed
Bwt0 (g)	Predose weight (0, 0.1, 0.3)	356, 362, 354	Fixed
$k_{\mathrm{s}}^{\text{Bwt}}(\mathrm{g}∕\mathrm{h})$ a	Weight gain rate constant (0, 0.1, 0.3)	117, 119, 117	10

^aSecondary parameter.