Table 1. Published papers of phase III randomised single agent fluoropyrimidine-based chemoradiation documenting pCR.
Trial | Patient numbers | Chemo | RT Dose | pCR | OS |
---|---|---|---|---|---|
NSABP RO3, Roh 2009 (27) | 267 | FUFA | 45 Gy/25#/33 days | 17% | 5 year 74% |
CA0/ARO/AIO-94 (Sauer 2004) (28) | 394 | 120 hour 5-FU infusion | 50.4 Gy/28#/38 days | 8% | 4 year 74% |
Polish study Bujko 2004, Bujko 2006 (29,30) | 157 | FUFA | 50 Gy/25#/33 days | 16% | 4 year 66% |
FFCD 9203 (Gerard 2006) (31) | 375 | FUFA | 45 Gy/25#/33 days | 11.4% | 5 year 66% |
EORTC 22921 (Bosset 2005,2006) (25,32) | 505 | FUFA | 45 Gy/25#/33 days | 13.4% | 5 year 65% |
All | 1,698 | 211/1,698 (12.4%) |