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Polycomb mediated silencing of gene expression. The polycomb repressive complex 2 (PRC2) silences chromatin by trimethylating lysine residue 27 (K27me3) of histone H3, causing chromatin compaction. H3K27me3 marked chromatin is bound by PRC1, which further silences gene expression by monoubiquitinating lysine residue 119 (K119Ub) of histone H2A.
