Figure 2.

(a). Heat maps of methylation differences discriminating obese asthmatics (OA) from (A) normal weight asthmatics (NwA), (B) obese non-asthmatics (Ob) and (C) healthy controls (HC). Red indicates more methylation and yellow less methylation by HELP-tagging. The columns represent subjects in each study group while the rows are the loci where the methylation difference between the two study groups being compared was greater than 20. (b). Proportional Venn diagram depicting overlap of differentially methylated CpG sites identified when obese asthmatics (OA) were compared to (A) normal-weight asthmatics (NwA), (B) Obese non-asthmatics (Ob) and (C) healthy controls (HC). Two hundred and fifteen loci were consistently differentially methylated in obese asthmatics compared to the other three groups.