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. 2013 Jul 16;3:2164. doi: 10.1038/srep02164

Table 2. Top fifty promoter loci with differential methylation between obese asthmatics and normal weight asthmatics.

ID Symbol Entrez Gene Name Methylation HpaII angle difference
Hypermethylated loci
NM_032808 LINGO1 leucine rich repeat and Ig domain containing 1 −26.75
NM_002457 MUC2 mucin 2, oligomeric mucus/gel-forming −30.20
NM_175875 SIX5 SIX homeobox 5 −30.22
NM_000674 ADORA1 adenosine A1 receptor −30.82
NM_012212 PTGR1 prostaglandin reductase 1 −36.04
NM_004292 RIN1 Ras and Rab interactor 1 −36.58
NM_030923 TMEM163 transmembrane protein 163 −36.66
NR_023315 ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 −37.41
NM_016396 CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) −39.70
NM_000577 IL1RN interleukin 1 receptor antagonist −41.41
NM_005514 HLA-B major histocompatibility complex, class I, B −46.27
NM_004979 KCND1 potassium voltage-gated channel, Shal-related subfamily, member 1 −46.61
NM_002002 FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) −47.49
NM_003327 TNFRSF4 tumor necrosis factor receptor superfamily, member 4 −46.31
NM_002617 PEX10 peroxisomal biogenesis factor 10 −47.88
NM_014700 RAB11FIP3 RAB11 family interacting protein 3 (class II) −48.80
NM_139172 TMEM190 transmembrane protein 190 −50.02
NM_006667 PGRMC1 progesterone receptor membrane component 1 −51.12
NM_032790 ORAI1 ORAI calcium release-activated calcium modulator 1 −51.61
NM_002384 MBD1 methyl-CpG binding domain protein 1 −53.69
NM_016396 CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) −54.03
NM_020343 RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) −54.91
NM_022143 LRRC4 leucine rich repeat containing 4 −58.71
NM_024617 ZCCHC6 zinc finger, CCHC domain containing 6 −59
NM_001769 CD9 CD9 molecule −63.28
Hypomethylated loci
NM_004356 CD81 CD81 molecule 22.89
NM_005905 SMAD9 SMAD family member 9 24.21
NM_002985 CCL5 chemokine (C-C motif) ligand 5 25.65
NM_006202 PDE4A phosphodiesterase 4A, cAMP-specific 25.78
NM_198836 ACACA acetyl-CoA carboxylase alpha 30.10
NM_006253 PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 30.29
NM_000229 LCAT lecithin-cholesterol acyltransferase 30.45
NM_181524 PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 32.71
NM_024782 NHEJ1 nonhomologous end-joining factor 1 35.34
NM_000283 PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 35.76
NM_017617 NOTCH1 notch 1 38.86
NM_007161 LST1 leukocyte specific transcript 1 42.42
NM_016592 GNAS GNAS complex locus 42.82
NM_006601 PTGES3 prostaglandin E synthase 3 (cytosolic) 42.85
NM_002641 PIGA phosphatidylinositol glycan anchor biosynthesis, class A 47.80
NM_003540 HIST1H4A histone cluster 1, H4a 47.36
NM_001807 CEL carboxyl ester lipase (bile salt-stimulated lipase) 47.79
NM_016541 GNG13 guanine nucleotide binding protein (G protein), gamma 13 47.74
NM_030928 CDT1 chromatin licensing and DNA replication factor 1 48.15
NM_213604 ADAMTSL5 ADAMTS-like 5 50.41
NM_022143 LRRC4 leucine rich repeat containing 4 52.43
NM_006668 CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 56.03
NM_002079 GOT1 glutamic-oxaloacetic transaminase 1, 56.28
NM_013361 ZNF223 zinc finger protein 223 61
NM_003073 SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin 64.52