Table 5. Molecules with differentially methylated gene promoters and their associated cellular functions in obese asthmatics (OA) compared to a) normal weight asthmatics (NwA), b) obese non-asthmatics (Ob) and c) healthy controls (HC).

OA vs NwA	OA vs Ob	OA vs HC
Function: Cell to cell signaling	Function: Chemotaxis of NK cells	Function: Differentiation of T lymphocytes
Hypomethylated gene promoters	Hypomethylated gene promoters	Hypomethylated gene promoters
a. Adam metallopeptidase domain (ADAM17) (pro-inflammatory enzyme causing ectodomain shedding of IL6 and TNFα)46	a. CCL5	a. ADAM17
b. Interleukin 2 receptor alpha (IL2RA) (member of high-affinity receptor for IL2, associated with increased Th1 differentiation)22	b. Prostaglandin D2 receptor (PGDR) (Regulates prostagladin D mediated mast cell and Th cell responses)53	b. IL2RA
c. Interleukin 27 (IL27) (induces maturation of T regulatory cells)47	c. G protein alpha 11 (GNA11) (involved in receptor mediated activation of signaling pathways)54	c. AHR
d. Leukemia inhibitory factor (LIF) (Proliferation of mature T cells)48	d. Phosphatidol inositol 3 kinase (PI3K) (involved in activation of signaling pathways)39Hypermethylated gene promoters	d. T box transcription factor (TBX21) (Th1 lineage defining transcription factor)23
e. Non homologous end joining factor 1 (NHEJ1) (associated with DNA repair; deficiency linked to immunodeficiency)49	e. G protein alpha 12 (GNA12) (involved in receptor mediated activation of signaling pathways)54	e. PRELI domain 1 (expressed in peripheral B lymphocytes and regulates STAT6)56
f. chemokine (C-C motif) ligand 5 (CCL5) (chemoattractant for mast cells, memory T cells)21Hypermethylated gene promoters	f. G protein alpha z polypeptide (GNAz) (involved in receptor mediated activation of signaling pathways)54	f. CCL5
g. Aryl hydrocarbon receptor (AHR)(regulates immune system, and cellular proliferation and migration)50	g. TNF receptor superfamily 1B (TNFSRF1B) (increased T cell and macrophage related inflammation)52	g. Colony stimulating factor 1 receptor (CSF1R) (macrophage production and differentiation)57Hypermethylated gene promoters
h. Chromodomain helicase DNA binding protein (CHD)51	h. IFNγ receptor 1 (IFNGR1)(binding site for IFNγ, site for interaction between monocytes and Tcells)55	h. CHD
i. TNF receptor superfamily 4 (TNFSRF4) (regulate development of memory and effector Tcells)52	i. FcεRII (FCER), low affinity receptor for IgE24	i. TGF beta (TGFB1) (produced by T regulatory cells to regulate immune responses)25
j. TNF receptor superfamily 9 (TNFSRF9) (activation of mast cells, CD4+ and CD8+ cells)52		j. TNFRSF4
k. FcεRII (FCER), low affinity receptor for IgE24