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. Author manuscript; available in PMC: 2013 Jul 16.
Published in final edited form as: Bioorg Med Chem Lett. 2008 Sep 12;18(20):5424–5427. doi: 10.1016/j.bmcl.2008.09.039

Scheme 1.

Scheme 1

Synthesis of 2-oxoamide 12. Reagents: (a) CH3(CH2)13CHOHCOOH, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, HOBt, Et3N, CH2Cl2; (b) AcNH-TEMPO, NaOCl, NaBr, EtOAc=PhCH3=H2O; (c) 50% TFA=CH2Cl2.