Figure 4.

Oocyte aneuploidy and spindle formation/chromosome alignment. (top left) The MII oocytes from control mice display a typical barrel-shaped spindle and organized chromosomes on the metaphase plate. Oocytes from HFD mice (top right) have abnormal fragmented spindles and clustered chromosomes. (lower panel) Quantitative analysis demonstrates that both spindle defects and chromosome misalignment are higher in obese mice than in control mice. Reproduced with permission from Luzzo et al. (2012).