Figure 4.

Estradiol (E₂) levels in the culture medium of in vitro-developed macaque follicles: (A) E2 secretion patterns of primary follicles cultured in FIBRIN, (B) E2 levels of growing follicles at Week 13 for primary follicle culture, (C) E2 secretion patterns of secondary follicles cultured in alginate, (D) E2 levels of slow- and fast-growing follicles at Week 5 for secondary follicle culture. Significant differences over time (lowercase) or between-follicle categories (uppercase) are indicated by different letters (P < 0.05). Data are presented as the mean ± SEM with 7 animals per group. *P < 0.05.