Table 3.
Distribution of tumor site (primary vs. metastasis) and Ki-67 labeling index according to SDHB expression (percentage of positive tumor cells) and immunstaining intensity.
| SDHBExpression | SITE | Ki-67 labeling index | ||||
|---|---|---|---|---|---|---|
| Primary Tumor | Metastases | p Value | ≤1.3% | ≥1.3% | p Value | |
| 1–25% | 2 | 3 | 1 | 4 | ||
| 26–50% | 2 | 7 | 0.013 (trend) | 3 | 6 | 0.038 |
| 51–75% | 7 | 8 | 8 | 7 | ||
| 76–100% | 9 | 1 | 7 | 3 | ||
| SDHB Intensity | ||||||
| 1+ | 1 | 18 | 2 | 17 | ||
| 2+ | 8 | 1 | <0.0001(trend) | 7 | 2 | <0.0001(trend) |
| 3+ | 11 | 0 | 10 | 1 | ||
Ki-67 labeling index: 1.3% represented the median value and was chosen as cut-off for distinguishing slower from faster growing tumors within the G1 category.