Figure 2.

The HA Interactome. HA is produced at the plasma membrane of cancer cells and/or stromal cells by HAS enzymes and is extruded to the extracellular space where it forms a meshwork with its interacting molecules, the hyaladherins, playing multiple complex roles in cell adhesion, motility and proliferation. This diagram emphasizes interactions between HA and its binding molecules, and downstream secondary and tertiary interactions. Although shown as a single interactome in this figure, the indicated interactions might be cell type- and condition-dependent.