Table 1.
List of miRNAs discussed in the text with their relevant functions and targets in GBMs or other cancers.
| MicroRNA functions | MicroRNAs | Relevant targets | Reference |
|---|---|---|---|
| Glioma stem cells | miR-124 | PTBP1, CDK6, SCP1, LAMC1, ITGB1 | [106,107,108,109,110,111,112,113] |
| miR-137 | CDK6 | ||
| miR-128 | Bmi-1, E2F3A | ||
| miR-7 | EGFR, IRS2 | ||
| miR-425 | |||
| miR-486 | |||
| miR-451 | |||
| miR-34a | Notch1, Notch2 | ||
| miR-326 | Notch | ||
| Pro-agiomiRs | miR-126, | Spred-1, PIK3R2 | [114,115,116,117,118,119,120,121,122,123,124,125,126] |
| miR-17-92 cluster | TSP-1 | ||
| miR-378 | Sufu, Fus-1 | ||
| miR-296 | HGS | ||
| miR-21 | |||
| miR-210 | Ephrin-A3 | ||
| miR-130a | HOXA5, GAX | ||
| miR-125b | MAZ | ||
| miR-101 | EZH2 | ||
| Anti-angiomiRs | miR 221/222 | c-Kit | [127,128] |
| miR-320 | IGF-1 | ||
| Aerobic glycolysis & related signaling pathways | miR-326 | PKM2 | [129,130,131] |
| miR-21 | PI3K/AKT/P53 | ||
| miR-26a, | PI3K/AKT | ||
| miR-221/222 | PI3K/AKT | ||
| miR-451 | LKB1/AMPK | ||
| miR-128 | AKT | ||
| miR-25 | P53 | ||
| mir-32 | P53 | ||
| miR-34a | MYC | ||
| miR-155/143 | CEBPb | ||
| mir-23a/b | MYC | ||
| Hypoxamirs | miR-20b | Sirt1 | [132,133,134,135] |
| miR-210 | ISCU1/2 | ||
| miR-199a | HIF-1α, Sirt1 |