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Interactions amongst Super Elongation Complex components (A) AF4, AFF4, AF9, ENL, pTEFb, DOT1L, ELL and EAF protein complexes are linked together by a series of different interactions. BRD4 and PAF1C are also linked to the SEC via interactions with pTEFb and AF9/ENL, respectively. Recent data have also suggested the possibility that AF9/ENL might bind TFIID; (B) AF9/ENL interacts with the H3K79 methyltransferase DOT1L in a complex that excludes other interacting partners.
