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. Author manuscript; available in PMC: 2013 Jul 16.
Published in final edited form as: Chem Biol Drug Des. 2012 Jan 30;79(4):470–477. doi: 10.1111/j.1747-0285.2011.01288.x

Table 3.

Variations of carboxylic acids and praziquantel derivatives 10(a-h)graphic file with name nihms-343095-t0032.jpg

Entry R3CO2H
5(a-h) 		Product 10
(a-h) 		Yield (%)a
1 graphic file with name nihms-343095-t0033.jpg graphic file with name nihms-343095-t0034.jpg 10a 58
2 graphic file with name nihms-343095-t0035.jpg graphic file with name nihms-343095-t0036.jpg 10b 42
3 graphic file with name nihms-343095-t0037.jpg graphic file with name nihms-343095-t0038.jpg 10c 44
4 graphic file with name nihms-343095-t0039.jpg graphic file with name nihms-343095-t0040.jpg 10d 25
5 graphic file with name nihms-343095-t0041.jpg graphic file with name nihms-343095-t0042.jpg 10e 29
6 graphic file with name nihms-343095-t0043.jpg graphic file with name nihms-343095-t0044.jpg 10f 10
7 graphic file with name nihms-343095-t0045.jpg graphic file with name nihms-343095-t0046.jpg 10g 19
8 graphic file with name nihms-343095-t0047.jpg graphic file with name nihms-343095-t0048.jpg 10h 25
a

Overall isolated yield for two steps.