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. Author manuscript; available in PMC: 2013 Jul 16.

Published in final edited form as: Chem Biol Drug Des. 2012 Jan 30;79(4):470–477. doi: 10.1111/j.1747-0285.2011.01288.x

Table 4.

Late-stage modification of praziquantel derivative 8d and 10d graphic file with name nihms-343095-t0049.jpg

Entry	R⁴	R⁵	R⁶	R⁷	%^c
1^a					71
2^a					46
3^b		H		H	98
4^b		H		H	97
5^b		H		H	81
6^b		H		H	91
7^b		H		H	93

^a

Condition A, Amine, 20% TBD, 60 °C.

^b

Condition B: Amine, K₂CO₃, DMF, rt.

^c

Isolated yield. TBD = 1,5,7-triazabicyclo[4.4.0]dec-5-ene.