Table 5.

50% effective concentration of schistosoma mansoni worm killing for different PZQ derivatives

Compound	EC₅₀ [μM]^a	Compound	EC₅₀ [μM]^a
S.mansoni PZQ	0.18	10b	3.9^* ^#
PZQ (synthetic)	0.37^c	10c	46.8^* ^#
8a	9.7^* ^#	10d	9.9^* ^#
8b	NE	10e	>100^* ^#
8c	0.9^* ^#	10f	>100^* ^#
8d	>100^* ^#	10g	NE
8e	>100^* ^#	10h	NE
9a	1.3^* ^#	11a	NE
9b	>100^* ^#	11b	>100^* ^#
9c	NE	11c	NE
9d	43.7^* ^#	11d	NE
9e	>100^* ^#	11e	NE
9f	>100^* ^#	11f	NE
10a	NE	11g	NE

NE = No effect.

Significant difference from the mother brand of PZQ at P<0.05.

Significant difference from the synthetic PZQ at P<0.05.

comparable sensitivity to mother PZQ with no statistically significant difference.