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. Author manuscript; available in PMC: 2013 Jul 16.
Published in final edited form as: J Control Release. 2013 Jan 13;167(1):53–59. doi: 10.1016/j.jconrel.2013.01.007

Table 1.

Pharmacokinetics of BDI vs. topical drops in aqueous humor and vitreous humor of NZW rabbits.

Parameter Low dose: 300 μg High dose: 600 μg Topical Drops
Aqueous humor Vitreous humor Aqueous humor Vitreous humor Aqueous humor Vitreous humor
Cmax (ng/mL) 650 ± 109 892 ± 151 1570 ± 113 1379 ± 233 62 ± 24 3 ± 0
Tmax (day) 19 ± 8 28 ± 0 7 ± 0 28 ± 0 14 ± 0 16 ± 11
AUC0-t (day*ng/mL) 15231 ± 361 18317 ± 2435 28202 ± 3369 32933 ± 4027 1023 ± 320 61 ± 5
Clast (ng/mL) 8 ± 3 2 ± 1 52 ± 18 85 ± 23 6 ± 2 2 ± 1