Table 1.

HBV DNA kinetic patterns under therapy

Drug effectiveness, εtot, and patient’s critical drug efficacy, εc	Ratio of HBV- infected cells to uninfected cells at the start of therapy [I:T]	Ratio of (T+I) to Tmax at start of therapy	HBV DNA decay pattern	Example
εtot<εc	I:T<1	(T+I):Tmax~1	flat 2nd phase	Fig. 2A; Fig. 3C
	I:T>1	(T+I):Tmax~1	complex decay in approaching flat phase	Fig. 2B; Lewin et al. (2)
	any I:T	(T+I):Tmax<<1	rebound	Fig. 2D; Fig. 3D
εtot~ εc(εtot< εc)	I:T<1	0<(T+I):Tmax≤1	intermediate slope phase that approaches a final flat phase	Fig. 2A; Heathcote et al. (30)
εtot>εc	I:T<1	0<(T+I):Tmax≤1	biphasic	Fig. 2A; Fig. 3A
	I:T>1	0<(T+I):Tmax≤1	triphasic	Fig. 2B; Fig. 3B