Table 3.
Pathology of Benign Nodules
| Number (%) (n=65) |
FDG-PET Avid a (n=26) |
FDG-PET Non-avid (n=16) |
|
|---|---|---|---|
| Granulomatous disease: | 37 (57%) | 15 | 9 |
| Active infectious: | 27 (42%) | ||
| Histoplasmosis | 15 (23%) | 5 | 3 |
| Atypical Mycobacteria | 2 (3%) | - | 1 |
| Blastomycosis | 2 (3%) | 1 | - |
| Cryptococcus | 2 (3%) | 1 | - |
| Mycobacterium tuberculosis | 1 (1.5%) | 1 | - |
| Aspergillus | 1 (1.5%) | - | - |
| Actinomyces | 1 (1.5%) | 1 | - |
| Nocardia | 1 (1.5%) | - | 1 |
| Mucor | 1 (1.5%) | - | - |
| Organism unknown | 1 (1.5%) | 5 | 4 |
| Healed or non-specific | 10 (15%) | - | - |
| Benign Tumors: | 10 (15%) | 2 | 5 |
| Hamartoma | 6 (9%) | 1 | 3 |
| Assorted benign tumors b | 4 (6%) | 1 c | 2 d |
| Fibrosis | 8 (12%) | 3 | 2 |
| Autoimmune and Vasculitides: | 6 (9%) | 3 | - |
| Wegener Granulomatosis | 3 (5%) | 2 | - |
| Pneumonitis | 1 (1.5%) | 1 | - |
| Rheumatoid | 1 (1.5%) | - | - |
| Churg-Strauss vasculitis | 1 (1.5%) | - | - |
| Other e | 4 (6%) | 3 | - |
a
FDG-PET Avid defined as SUV > 2.5 or mild, moderate, or intense uptake, or radiology report indicated suspicion of cancer
b
Assorted Benign Tumors: Lipoma, Premalignancy was specified in the pathologist’s report for (1) inflammatory myofibroblastic, (2) atypical lymphoproliferative, and (3) neuroendocrine cell hyperplasia.
c
Inflammatory myofibroblastic
d
Atypical lymphoproliferative and Lipoma
e
Other: Bronchiolitis obliterans organizing pneumonia, Broncholith with post-obstructive pneumonia, Reactive lymph nodes, Infarct with organizing thrombus