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. Author manuscript; available in PMC: 2013 Jul 16.
Published in final edited form as: Chem Rev. 2012 Mar 22;112(6):3083–3135. doi: 10.1021/cr100233r

Figure 21.

Figure 21

vL-3CR compound SB220025 is a potent p38 inhibitor. Above: Binding of SB220025 into p38 active site (PDB ID: 1BL7). The 2-amino portion forms hydrogen bonds, the kinase hinge region and the fluorine of the ligand is involved in a short contact to the backbone carbonyl-C (3.1 Å). Below: reaction scheme of the vL-3CR.