Table 3. Comparative Rates of Recanalization, Symptomatic Intracranial Hemorrhage and Functional Outcome in Various Clinical Trials .
| Revascularization approach | Partial and incomplete recanalization (%) | SICH | mRS 0 - 2 at 3 months |
|---|---|---|---|
| IV tPA < 3 hrs CLOTBUST [28], TUCSON [80] | 40 | 4.4 | 39 |
| IA Pro-urokinase < 6 hrs PROACT II trial [35] | 66 | 10 | 40 |
| IV tPA < 3 hrs + IA tPA IMS II trial [70] | 64 | 9.9 | 38 |
| MerciTM < 8 hrs [44], Multi-Merci Study [50] | 57 | 9.8 | 36 |
| PenumbraTM < 8 hrs Penumbra clinical study [55] | 82 | 11.2 | 25 |
| IV tPA sonothrombolysis < 3hrs CLOTBUST tPA + TCD arm [28] | 83 | 3.8 | 51 |
tPA: tissue plasminogen activator; SICH: symptomatic intracranial hemorrhage; mRS: modified Rankin Scale; PRO-UK: Pro-Urokinase.