Table 1.

Tick molecules interfering with Borrelia acquisition, persistence and/or transmission.

Name	Supposed function	RNAi effect on the pathogen	References
Tick receptor for OspA (TROSPA)	Unknown	Reduced acquisition	Pal et al., 2004
Salivary protein 15 (Salp15)	Inhibition of the host complement system	Decreased transmission	Ramamoorthi et al., 2005
Salivary protein 25D (Salp25D)	Glutathione peroxidase	Decreased acquisition	Narasimhan et al., 2007b
Tick histamine release factor (tHFR)	Stimulation of histamine release	Decreased transmission	Dai et al., 2010
Tick receptor of BBE31 (tre31)	Unknown	Reduced persistence	Zhang et al., 2011
Tick salivary lectin pathway inhibitor (TSLPI, P8)	Inhibition of the host complement system	Decreased persistence and transmission	Schuijt et al., 2011a