Table 2.
Tick molecules interfering with Anaplasma acquisition and/or transmission.
| Name | Supposed function | RNAi effect on the pathogen | References |
|---|---|---|---|
| Salivary protein 16 (Salp16) | Unknown | Decreased acquisition | Sukumaran et al., 2006 |
| Subolesin (SUB) | Component of the immune signaling pathways | Decreased acquisition | De La Fuente et al., 2006, 2008; Merino et al., 2011; Busby et al., 2012 |
| Varisin | Defensin | Decreased acquisition | Kocan et al., 2008b |
| Vacuolar H+ ATPase (vATPase) | Acidification of vesicles | Decreased acquisition | De La Fuente et al., 2007a; Kocan et al., 2009 |
| Ubiquitin | Protein degradation | Decreased acquisition | De La Fuente et al., 2007a; Kocan et al., 2009 |
| Glutathione S-transferase (GST) | Detoxification and signaling | Decreased acquisition | De La Fuente et al., 2007a; Kocan et al., 2009 |
| Salivary selenoprotein M (SelM) | Protection against oxidative stress | Decreased acquisition | De La Fuente et al., 2007a; Kocan et al., 2009 |
| α-1,3 fucosyltransferase (IsFT) | Glycosylation of proteins | Decreased acquisition | Pedra et al., 2010 |
| G protein-coupled receptor Gβγ subunits (Gβγ) | Signal transduction | Decreased acquisition | Sultana et al., 2010 |
| Phosphoinositide 3-kinase (pak1) | Cytoskeletal reorganization and signaling | Decreased acquisition | Sultana et al., 2010 |
| p21-activated kinase (pi3k) | Cytoskeletal reorganization and signaling | Decreased acquisition | Sultana et al., 2010 |
| Protein 11 (P11) | Unknown | Decreased acquisition | Liu et al., 2011 |
| Heat-shock protein 20 (Hsp20) | Cellular stress response | Increased acquisition | Busby et al., 2012 |
| Heat-shock protein 70 (Hsp70) | Cellular stress response | Decreased acquisition | Busby et al., 2012 |
| Janus kinase (JAK) | Component of JAK/STAT signaling pathway | Increased acquisition | Liu et al., 2012 |
| Signal transducer and activator of transcription (STAT) | Component of JAK/STAT signaling pathway | Increased acquisition and transmission | Liu et al., 2012 |
| Gene-15 | Antimicrobial peptide | Increased acquisition and transmission | Liu et al., 2012 |
| X-linked inhibitor of apoptosis protein (XIAP) | E3 ubiquitin ligase | Increased acquisition | Severo et al., 2013 |
| α-fodrin (CG8) | Spectrin α-chain | Decreased acquisition | Ayllón et al., 2013 |
| Porin (T2) | Mitochondrial voltage-dependent anion-selective channel | Decreased acquisition | Ayllón et al., 2013 |