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. 2013 Jul 16;8(7):e68907. doi: 10.1371/journal.pone.0068907

Table 4. Selection of TAM and RU486 regulated gene products in Ishikawa cells related to reproductive system diseases.

Selection of TAM regulated gene products related to reproductive system diseases
FunctionsAnnotation p-Value Molecules
adenomyosis 2,12E-05 AIG1,ANXA2,CBX6,CXXC5,DST,IQGAP1,LDHA,MALAT1,MTHFD2,TCF4,THBS1,TSPAN12
genital tumor 4,90E-05 ABCB1,ABR,ALDH3A1,ALPP/ALPPL2,ANTXR1,ANXA2,AR,ASS1,ATP1A1,BMPR1B,C9orf5,CCND1,CD44,CDH1,CDH2,CLU,COL18A1,CXXC5,ECT2,EGFL7,EHF,ENO1,EP300,EPHA2,ERBB3,ETV1,FGFR1,FGFR2,FHL2,FN1,GPC1,GPRC5A,GSTP1,HDAC4,HDAC6,HSP90AA1,ING4,ITGB4,JAG2,KIF1B,KRT23,KRT7,LDHA,LETM1,LRP5,LRRN4,MAPK8,MECOM,MKI67,MTHFD2,MYC,NCOR2,NTRK2,PAX8,PDE11A,PGR,PLEKHB1,PRC1,PSMD4,PTAFR,RACGAP1,S100A2,SAT1,SLC12A6,SLC16A3,SLC2A1,SLIT2,SMC4,SNAP25,SORT1,SRSF5,STIP1,TCF4,TFPI2,TMPRSS2,TOP2A,TRADD,TUBA1A,TUBE1,TUSC3,WT1,XIAP,ZNF217
gonadal tumor 1,66E-04 ABCB1,ALDH3A1,ALPP/ALPPL2,AR,CD44,CDH1,CLU,COL18A1,CXXC5,ECT2,ENO1,EP300,EPHA2,ERBB3,FGFR1,FGFR2,FN1,GSTP1,HDAC4,HDAC6,HSP90AA1,JAG2,KRT23,LDHA,LETM1,LRRN4,MECOM,MKI67,MTHFD2,PAX8,PGR,PTAFR,RACGAP1,S100A2,SLC12A6,SLC16A3,SLIT2,SMC4,SORT1,SRSF5,STIP1,TFPI2, TOP2A,TUBA1A,TUBE1,WT1,ZNF217
ovarian cancer 1,94E-04 ABCB1,ALDH3A1,AR,CD44,CDH1,CLU,COL18A1,CXXC5,ECT2,ENO1,EP300,EPHA2,ERBB3,FGFR1,FGFR2,FN1,GSTP1,HDAC4,HDAC6,HSP90AA1,JAG2,KRT23,LETM1,LRRN4,MECOM,MTHFD2,PAX8,PGR,PTAFR,RACGAP1,S100A2,SLC12A6,SLC16A3,SLIT2,SMC4,SORT1,SRSF5,STIP1,TFPI2,TOP2A,TUBA1A,TUBE1,WT1, ZNF217
gynecologicaldisorder 2,20E-04 ABCB1,AIG1,ALDH3A1,ANXA1,ANXA2,AR,ARL4D,ATRX,CBX6,CD44,CDH1,CDH2,CEP70,CLU,COL18A1,CTSF,CXXC5,DST,ECT2,ENO1,EP300,EPHA2,ERBB3,FGFR1,FGFR2,FN1,FOXM1,GLIPR1,GNG11,GSTP1,HDAC4,HDAC6,HSP90AA1,HSPB1,IGFBP5,IGFBP7,IQGAP1,ITGB8,JAG2,JUP,KIAA0664,KRT23,LDHA,LETM1,LRRN4,LTBP1,LTBP4,MALAT1,MECOM,MKI67,MR1,MTHFD2,MYC,NEK2,OLFM1,PAX8,PGR,PLD3,POLG,PTAFR,RACGAP1,RAD51B,RAPGEF3,S100A2,S100A4,SLC12A6,SLC16A3,SLIT2,SMC4,SORT1,SRSF5,STIP1,TAGLN,TCF4,TFPI2,TGFBR3,THBS1,TMSB10/TMSB4X,TOP2A,TPM2,TSPAN12,TUBA1A,TUBE1,WT1,ZNF217,ZNF350
cervical cancer 1,91E-03 ANXA1,ANXA2,CDH1,CDH2,CTSF,ENO1,FGFR1,FGFR2,FOXM1,GSTP1,HSP90AA1,HSPB1,ITGB8,JUP,LETM1,MKI67,PGR,SLC12A6,TAGLN,TMSB10/TMSB4X,TOP2A,TPM2,TUBA1A,TUBE1,ZNF350
uterine cancer 1,03E-02 AIG1,ANXA1,ANXA2,AR,ARL4D,CDH1,CDH2,CTSF,DST,ENO1,FGFR1,FGFR2,FOXM1,GLIPR1,GNG11,GSTP1,HSP90AA1,HSPB1,IGFBP5,IGFBP7,IQGAP1,ITGB8,JUP,KIAA0664,LETM1,LTBP1,LTBP4,MALAT1,MKI67,MR1,MTHFD2,MYC,OLFM1,PGR,PLD3,RAD51B,RAPGEF3,S100A4,SLC12A6,TAGLN,TMSB10/TMSB4X,TOP2A, TPM2,TSPAN12,TUBA1A,TUBE1,WT1,ZNF350
amenorrhea 1,30E-02 AR,PGR,TGFBR3
metrorrhagia 1,53E-02 AR,PGR
serous ovariancarcinoma 3,78E-02 CLU,CXXC5,JAG2,LRRN4,PGR,PTAFR,RACGAP1,S100A2,SLIT2,SMC4,SORT1,TFPI2
disorder of ovary 3,90E-02 AR,ATRX,CEP70,ECT2,NEK2,PGR,POLG,TGFBR3
polycystic ovarysyndrome 4,90E-02 AR,ATRX,CEP70,ECT2,NEK2,PGR
Selection of RU486 regulated gene products related to reproductive system diseases
gynecologicaldisorder 5,96E-04 AGR2,ALDH3A1,AR,ARL4D,AURKB,C18orf1,CALCRL,CBX6,CDC7,CDH2,CDKN2A,CTNNAL1,CTNND1,EME1,ENO1,EPCAM,ERBB3,FGFR2,FN1,H2AFX,HDAC4,HDAC7,HDAC9,IQGAP1,JUP,KAT2B,KIAA0664,KRT23,LDHA,MALAT1,MCAM,MECOM,MYC,OLFM1,PAX8,PCM1,PDK4,PGR,RAD51B,RASSF9,RNF144B,SLC16A3,SYNC,TAGLN,TAX1BP1,TCF4,THBS1,TMSB10/TMSB4X,ZDHHC17,ZNF138,ZNF350
adenomyosis 8,84E-04 CBX6,IQGAP1,LDHA,MALAT1,SYNC,TCF4,THBS1
gonadal tumor 3,65E-03 AGR2,ALDH3A1,ALPP/ALPPL2,AR,CDKN2A,CTNNAL1,ENO1,EPCAM,ERBB3,FGFR2,FN1,H2AFX,HDAC4,HDAC7,HDAC9,KAT2B,KRT23,LDHA,MCAM,MECOM,PAX8,PGR,RASSF9,RNF144B,SLC16A3,ZNF138
metrorrhagia 4,64E-03 AR,PGR
uterine leiomyoma 4,74E-03 ARL4D,AURKB,C18orf1,CALCRL,CDC7,CTNND1,IQGAP1,KIAA0664,MALAT1,MYC,OLFM1,PDK4,PGR,RAD51B,ZDHHC17
ovarian cancer 5,10E-03 AGR2,ALDH3A1,AR,CDKN2A,CTNNAL1,ENO1,EPCAM,ERBB3,FGFR2,FN1,H2AFX,HDAC4,HDAC7,HDAC9, KAT2B,KRT23,MCAM,MECOM,PAX8,PGR,RASSF9,RNF144B, SLC16A3, ZNF138
polycystic ovarysyndrome 1,45E-02 AR,EME1,PCM1,PGR,TAX1BP1
genital tumor 1,77E-02 AGR2,ALDH3A1,ALPP/ALPPL2,AR,ARG2,AURKB,CDH2,CDKN2A,CGN,CTNNAL1,EHF,ENO1,EPCAM,ERBB3,FGFR2,FHL2,FN1,H2AFX,HDAC4,HDAC7,HDAC9,KAT2B,KRT23,LDHA,MCAM,MECOM,MTA1,MYC,NCOR2,NTRK2,OAZ1,PAX8,PGR,RASSF9,RCAN2,RNF144B,SLC16A3,TCF4,TMPRSS2,ULK3,ZNF138
atypical endometrialhyperplasia 2,84E-02 PGR
metastasis of cervicalcancer cell lines 2,84E-02 ZNF350
preterm birth 2,84E-02 PGR
primaryhypogonadism 2,84E-02 AR
subfertility 2,84E-02 PGR
serous ovariancarcinoma process 3,07E-02 CTNNAL1,EPCAM,H2AFX,MCAM,PGR,RASSF9,RNF144B,ZNF138
amenorrhea 3,11E-02 AR,PGR
The categories related to male infertility and breast cancer are excluded