Table 1. Clinical Studies addressing Duration of Storage of Transfused Red Blood Cells and Patient Outcomes.
| First Author, Year | Population | Number | Clinical Outcomes | |
| SIGNIFICANT ASSOCIATION | ||||
| Martin 1994 [10] | Critical Care | 698 | Increased LOS | |
| Purdy 1997 (11] | Critical Care | 31 | Increased mortality | |
| Zallen 1999 [18] | Trauma | 63 | Increased multiorgan failure | |
| Vamvakas 1999 [14] | Cardiac Surgery | 416 | Increased postoperative pneumonia | |
| Mynster 2000 [25] | Colorectal Cancer | 303 | Increased overall infection rate | |
| Offner 2002 [21] | Trauma | 61 | Increased infection rate | |
| Keller 2002 [22] | Trauma | 86 | Increased LOS | |
| Murrell 2005 [19] | Trauma | 275 | Longer ICU stay | |
| Koch 2008 [13] | Cardiac Surgery | 6,002 | Increased in-hospital mortality and sepsis | |
| Weinberg 2008 [20] | Trauma | 1,813 | Increased mortality | |
| Spinella 2009 [23] | Trauma | 202 | Increased DVT and mortality | |
| Eikelboom 2010 [15] | Cardiac Surgery | 4,993 | Increased mortality | |
| Robinson 2010 [39] | Cardiology* | 909 | Increased 30 day mortality | |
| Pettila 2011 [12] | Critical Care | 757 | Increased mortality | |
| Sanders 2011 [17] | Cardiac Surgery | 176 | Increased postoperative LOS | |
| Andreasen 2011 [16] | Cardiac Surgery | 4,240 | Increased postoperative infections | |
| NO ASSOCIATION | ||||
| Edna 1998 [26] | Colorectal Cancer | 446 | Postoperative Infections | |
| Vamvakas 2000 [40] | Cardiac surgery | 268 | LOS, ICU LOS, and length of intubation | |
| Leal-Noval 2003 [41] | Cardiac surgery | 897 | ICU LOS, mechanical ventilation time, perioperative MI, postoperative infection | |
| Hebert 2005 [42] | Cardiac Surgery/Critical Care | 57 | Mortality | |
| Van der Watering 2006 [43] | Cardiac surgery | 2,732 | Mortality and ICU LOS | |
| Taylor 2006 [44] | Critical Care | 2,085 | Nosocomial infections | |
| Dessertaine 2008 [45] | Critical Care | 534 | Mortality | |
| Yap 2008 [46] | Cardiac surgery | 670 | Mortality, renal failure, pneumonia, ICU LOS | |
| Kekre 2011 [24] | HSCT | 555 | Mortality, LOS, organ toxicity | |
| VanStraten 2011 [47] | Cardiac Surgery | 5,316 | Mortality | |
| Katsios 2011 [48] | Critical Care | 126 | DVT | |
| Dunn 2012 [49] | Liver transplant | 509 | Infection, organ failure, mortality | |
*
Patients who underwent percutaneous coronary intervention;
LOS = length of stay; ICU = intensive care unit; DVT = deep vein thrombosis; MI = myocardial infarction; HSCT = hematopoietic stem cell transplantation.