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. 2013 Jul 16;8(7):e68154. doi: 10.1371/journal.pone.0068154

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Isolated hearts were subjected to ex vivo ischemia/reperfusion injury (30 min/30 min) as detailed in Materials and Methods. Left ventricular developed pressure (LVDP) and infarct size were measured as detailed in Materials and Methds. Recovered LVDP, expressed as the per cent of baseline LVDP, was significantly reduced in the NTT-MMP-2 transgenic hearts. Infarction size was increased by nearly 50% in the transgenic hearts. (n = 5–6 for each study group; * P<0.05).