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. 2013 Jul 16;8(7):e68335. doi: 10.1371/journal.pone.0068335

Table 9. Up-regulated genes in the MCA that are exclusive to ‘hypertension plus hypercholesterolemia’ rabbits vs. sham controls with greater than 4-fold change.

Gene GeneSymbol Corrected p-value Hypertension plus hypercholesterolemia
Fold change
schlafen family member 14 SLFN14 0.00614 13.64
MRS2 magnesium homeostasis factor homolog (S. cerevisiae) MRS2 0.00000 8.85
HEAT repeat containing 3 LOC100357872 0.00100 8.34
membrane-spanning 4-domains, subfamily A, member 2 MS4A2 0.00891 8.29
kinesin family member 21A KIF21A 0.00003 7.31
N(alpha)-acetyltransferase 25, NatB auxiliary subunit NAA25 0.00099 7.23
General transcription factor IIB LOC100359058 0.00015 7.00
interleukin 20 receptor, alpha IL20RA 0.00000 6.96
solute carrier family 18 (vesicular monoamine), member 1 SLC18A1 0.00074 6.64
IQ motif and ubiquitin domain containing IQUB 0.00104 6.64
family with sequence similarity 71, member C FAM71C 0.00026 6.63
secretoglobin, family 3A, member 1 SCGB3A1 0.00010 6.42
STAM binding protein-like 1 STAMBPL1 0.00286 6.39
tripartite motif-containing 67 TRIM67 0.00175 6.39
Serum response factor binding protein 1-like LOC100349313 0.00139 6.34
G protein-coupled receptor 119 GPR119 0.00058 6.30
2′,3′-cyclic nucleotide 3′ phosphodiesterase CNP 0.00000 6.14
steroidogenic acute regulatory protein STAR 0.00007 6.05
CD4 molecule (CD4) CD4 0.00004 6.02
DOMON domain-containing protein FRRS1L FRRS1L 0.00003 5.99
Tubulin tyrosine ligase-like family, member 5 LOC100359240 0.00019 5.99
thymidine phosphorylase TYMP 0.00005 5.87
dynein heavy chain domain 1 DNHD1 0.00134 5.87
Insulin-like 5 INSL5 0.00018 5.85
Transcription elongation factor A (SII)-like 2-like LOC100340955 0.00015 5.75
Solute carrier family 5 (sodium/glucose cotransporter), member 9 SLC5A9 0.00002 5.73
Kruppel-like factor 13 KLF13 0.00007 5.69
Granulate-macrophage stimulating factor (Predicted) GMCSF 0.00004 5.68
listerin E3 ubiquitin protein ligase 1 LTN1 0.00009 5.66
carboxylesterase 8 (putative) CES4A 0.00023 5.63
C-type lectin domain family 1, member B CLEC1B 0.00584 5.60
solute carrier family 15, member 5 SLC15A5 0.00075 5.55
glucosidase, beta, acid 3 (cytosolic) GBA3 0.00012 5.55
Proline-rich protein 3 (MHC class I region proline-rich protein CAT56) PRR3 0.00129 5.50
chemokine (C-C motif) ligand 19 CCL19 0.00055 5.50
AchR epsilon subunit CHRNE 0.00010 5.43
Transmembrane protein C5orf28 C5orf28 0.00319 5.38
dehydrogenase/reductase (SDR family) member 9 DHRS9 0.00168 5.37
FCH and double SH3 domains 1 FCHSD1 0.00015 5.37
Uncharacterized protein C7orf72 C2orf72 0.00114 5.35
family with sequence similarity 71, member F2 FAM71F2 0.00643 5.34
otopetrin 2 OTOP2 0.00006 5.31
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 ELOVL3 0.00012 5.30
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 SLC7A13 0.00134 5.30
Uncharacterized protein C2orf71 C2orf71 0.00177 5.30
solute carrier family 14 (urea transporter), member 1 (Kidd blood group) SLC14A1 0.00027 5.21
RAS guanyl releasing protein 4 RASGRP4 0.00058 5.11
ATPase, class I, type 8B, member 2 ATP8B2 0.00360 5.07
Cytochrome P450, family 4, subfamily A, polypeptide 5 CYP4A5 0.00061 5.05
Pregnancy-zone protein PZP 0.00652 5.02
ATPase, H+/K+ exchanging, alpha polypeptide (ATP4A) ATP4A 0.00000 5.02
CD2 molecule CD2 0.00064 4.99
3-oxo-5-alpha-steroid 4-dehydrogenase 2-like LOC100343882 0.00001 4.99
phosphatidylcholine transfer protein PCTP 0.00001 4.96
transmembrane emp24 protein transport domain containing 6 TMED6 0.00040 4.96
actin-related protein T1 ACTRT1 0.00005 4.94
Wings apart-like homolog LOC100348678 0.00041 4.94
Fructose-1,6-bisphosphatase 1 FBP1 0.00050 4.88
neuron navigator 2 NAV2 0.00080 4.87
potassium channel tetramerisation domain containing 19 KCTD19 0.00123 4.87
spermatogenesis associated, serine-rich 1 SPATS1 0.00201 4.83
Solute carrier family 5 (sodium/glucose cotransporter), member 1 LOC100009262 0.00001 4.80
tripartite motif-containing 35 TRIM35 0.00084 4.80
cytochrome P450, family 26, subfamily C, polypeptide 1 CYP26C1 0.00224 4.79
Polymeric immunoglobulin receptor Precursor (Poly-Ig receptor)(PIGR) PIGR 0.00025 4.75
Ras and Rab interactor-like RINL 0.00135 4.71
ubiquitin associated and SH3 domain containing B UBASH3B 0.00803 4.70
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13) GALNT13 0.00000 4.70
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae) PRPF18 0.00144 4.68
spinster homolog 3 (Drosophila) SPNS3 0.00049 4.68
galactosidase, beta 1-like 3 GLB1L3 0.00003 4.67
iroquois homeobox 2 IRX2 0.00052 4.66
collagen, type XVII, alpha 1 COL17A1 0.00028 4.65
patched 2 PTCH2 0.00005 4.65
DEAQ box RNA-dependent ATPase 1 DQX1 0.00520 4.60
Potassium channel, subfamily K, member 1 KCNK1 0.00217 4.58
purinergic receptor P2Y, G-protein coupled, 10 P2RY10 0.00197 4.57
somatostatin receptor 2 SSTR2 0.00077 4.56
zinc finger, DHHC-type containing 19 ZDHHC19 0.00241 4.55
ret proto-oncogene RET 0.00036 4.55
Oxytocin receptor OXTR 0.00517 4.52
serine peptidase inhibitor, Kazal type 1 SPINK1 0.00055 4.50
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) MPP2 0.00409 4.50
solute carrier family 13 (sodium/sulfate symporters), member 1 SLC13A1 0.00325 4.49
follistatin-like 5 FSTL5 0.00071 4.49
Mitochondrial ribosomal protein S15-like LOC100345026 0.00064 4.49
TERF1 (TRF1)-interacting nuclear factor 2 TINF2 0.00325 4.49
keratin associated protein 19-4 KRTAP19-4 0.00044 4.48
XK, Kell blood group complex subunit-related, X-linked XKRX 0.00051 4.47
FK506 binding protein 1B, 12.6 kDa FKBP1B 0.00274 4.46
phospholipase C, zeta 1 PLCZ1 0.00002 4.45
CD244 molecule, natural killer cell receptor 2B4 CD244 0.00003 4.44
carboxyl ester lipase (bile salt-stimulated lipase) (CEL) CEL 0.00016 4.44
ADAM metallopeptidase with thrombospondin type 1 motif, 18 ADAMTS18 0.00213 4.43
UDP-glucuronosyltransferase UGT2C1 0.00035 4.42
fms-related tyrosine kinase 3 FLT3 0.00270 4.41
mitogen-activated protein kinase binding protein 1 MAPKBP1 0.00003 4.41
Ammonium transporter Rh type C (Rhesus blood group family type C glycoprotein)(Rh family type C glycoprotein)(Rh type C glycoprotein) RHCG 0.00032 4.41
Kelch-like 1 (Drosophila) KLHL1 0.00003 4.35
leucine rich repeat transmembrane neuronal 4 LRRTM4 0.00002 4.34
proteoglycan 3 PRG3 0.00254 4.33
Ligand of numb-protein X 1-like LOC100343259 0.00568 4.33
Chymase like protein LOC100008644 0.00060 4.32
sex comb on midleg-like 4 (Drosophila) SCML4 0.00854 4.32
BMS1-like, ribosome assembly protein LOC100339194 0.00017 4.31
Uncharacterized protein C2orf61 C2orf61 0.00893 4.31
Protein FAM55A LOC100009342 0.00326 4.30
cyclin-dependent kinase 15 CDK15 0.00129 4.28
Rac GTPase activating protein 1 pseudogene RACGAP1P 0.00023 4.27
family with sequence similarity 170, member A FAM170A 0.00008 4.23
Mitogen-activated protein kinase kinase kinase 4 MAP3K4 0.00788 4.22
ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A ATP6V1A 0.00397 4.19
FRY-like FRYL 0.00291 4.18
clusterin-like 1 (retinal) CLUL1 0.00072 4.17
Superiorcervical ganglia, neural specific 10 LOC100344464 0.00228 4.14
histamine receptor H1 HRH1 0.00001 4.13
Cingulin (Predicted) Cgn 0.00236 4.12
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta NFKBID 0.00103 4.12
ribonuclease, RNase A family, 1 (pancreatic) RNASE1 0.00043 4.11
Nuclear prelamin A recognition factor LOC100344024 0.00002 4.09
actin, beta-like 2 ACTBL2 0.00023 4.09
Ghrelin receptor LOC100101582 0.00062 4.08
olfactomedin 2 OLFM2 0.00385 4.07
COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) COX10 0.00160 4.07
ribonuclease L (2′,5′-oligoisoadenylate synthetase-dependent) RNASEL 0.00028 4.06
keratin associated protein 11-1 KRTAP11-1 0.00013 4.04
DnaJ (Hsp40) homolog, subfamily C, member 5 beta DNAJC5B 0.00016 4.03
receptor (chemosensory) transporter protein 1 RTP1 0.00012 4.03
protocadherin 8 PCDH8 0.00005 4.02
Ubiquitin specific protease 39 LOC100344046 0.00343 4.02
proline/serine-rich coiled-coil 1 PSRC1 0.00571 4.01
cadherin 17, LI cadherin (liver-intestine) CDH17 0.00459 4.00