. 2013 Jan 9;143(3):315–323. doi: 10.3945/jn.112.171322

TABLE 3.

Hepatic gene expression in Ldlr^−/− mice fed the NP, WD + OO, WD + EPA, WD + DHA, and WD + EPA + DHA diets for 16 wk and effects on mRNA abundance of enzymes involved in fatty acid synthesis and TG hydrolysis¹

Fatty acid synthesis	NP	WD + OO	WD + EPA	WD + DHA	WD + EPA + DHA
			fold of NP
Fasn	1.0 ± 0.4^a	0.6 ± 0.2^a,b	0.4 ± 0.1^b,c	0.2 ± 0.1^c	0.4 ± 0.1^b,c
Elovl1	1.0 ± 0.2^c	2.0 ± 0.4^a	1.8 ± 0.2^a,b	1.1 ± 0.2^c	1.5 ± 0.3^b
Elovl2	1.0 ± 0.4^c,d	1.5 ± 0.4^a	1.2 ± 0.3^a,b	0.6 ± 0.2^d	0.9 ± 0.2^b,c
Elovl3	1.0 ± 0.3^a	0.2 ± 0.1^b	0.3 ± 0.1^b	0.3 ± 0.1^b	0.3 ± 0.1^b
Elovl5	1.0 ± 0.3^c	2.1 ± 0.6^a,b	1.8 ± 0.4^a,b	1.0 ± 0.4^c	1.6 ± 0.5^b,c
Elovl6	1.0 ± 0.2^b,c	1.5 ± 0.4^a	1.4 ± 0.2^a,b	1.0 ± 0.4^c	1.3 ± 0.3^a,b,c
Elovl7	1.0 ± 0.2^b	5.5 ± 2.2^a	2.3 ± 1.6^b	2.1 ± 0.9^b	2.4 ± 0.9^b
Fads1	1.0 ± 0.3^a,b	1.1 ± 0.4^a	0.7 ± 0.2^b,c	0.2 ± 0.2^d	0.4 ± 0.2^c,d
Fads2	1.0 ± 0.2^b,c	2.0 ± 0.6^a	1.5 ± 0.2^b	0.8 ± 0.4^c	1.2 ± 0.2^b,c
Scd1	1.0 ± 0.7^c	6.0 ± 2.6^a	6.1 ± 2.6^a	2.4 ± 1.5^b,c	4.1 ± 1.5^a,b
TG hydrolysis
Atgl	1.0 ± 0.3	1.2 ± 0.3	1.2 ± 0.1	1.0 ± 0.3	1.3 ± 0.2
Tgh	1.0 ± 0.3^b	0.9 ± 0.4^b	1.2 ± 0.2^a,b	1.2 ± 0.5^a,b	1.5 ± 0.3^a
Aadac	1.0 ± 0.2	0.9 ± 0.3	0.9 ± 0.1	0.8 ± 0.3	0.9 ± 0.2
Adrp	1.0 ± 0.4	1.5 ± 0.3	1.4 ± 0.3	1.2 ± 0.4	1.3 ± 0.5
Adpn	1.0 ± 0.3^b	2.1 ± 0.9^a	1.3 ± 0.2^b	0.9 ± 0.2^b	1.4 ± 0.5^b

Values are mean ± SD, = 8/treatment group. Labeled means in a row with superscripts without a common letter differ, P ≤ 0.05. NP, nonpurified diet; WD + DHA, Western diet supplemented with DHA; WD + EPA, Western diet supplemented with EPA; WD + EPA + DHA, Western diet supplemented with EPA and DHA; WD + OO, Western diet supplemented with olive oil.