TABLE 3.
Meta-analyzed interactions between magnesium intake and SNPs on fasting glucose and fasting insulin in 15 cohort studies1
| SNP | Nearest gene | Coded allele | Other allele | Coded allele frequency | Number of cohorts | Interaction2 between 50-mg/d increment in magnesium intake × SNP on outcome |
|||
| n3 | β (95% CI) | P | I 2(95% CI) | ||||||
| Glucose-related SNPs | Outcome is fasting glucose (mmol/L) |
||||||||
| rs10830963 | MTNR1B | G | C | 0.28 | 15 | 51,257 | 0.0033 (−0.0006, 0.0072) | 0.10 | 47 (4, 71) |
| rs10885122 | ADRA2A | G | T | 0.89 | 15 | 52,068 | −0.0013 (−0.0064, 0.0038) | 0.64 | 15 (0, 53) |
| rs11071657 | C2CD4B | A | G | 0.62 | 15 | 52,098 | 0.0023 (−0.0012, 0.0058) | 0.21 | 0 (0, 35) |
| rs11558471 | SLC30A8 | A | G | 0.69 | 13 | 50,329 | −0.0045 (−0.0082, −0.0008) | 0.02 | 5 (0, 37) |
| rs11605924 | CRY2 | A | C | 0.48 | 15 | 52,264 | 0.0017 (−0.0016, 0.0050) | 0.30 | 41 (0, 68) |
| rs11708067 | ADCY5 | A | G | 0.78 | 14 | 50,829 | −0.0006 (−0.0047, 0.0035) | 0.78 | 12 (0, 51) |
| rs11920090 | SLC2A2 | T | A | 0.86 | 14 | 51,441 | −0.0019 (−0.0066, 0.0028) | 0.43 | 35 (0, 65) |
| rs174550 | FADS1 | T | C | 0.67 | 15 | 52,305 | −0.0022 (−0.0055, 0.0011) | 0.20 | 27 (0, 61) |
| rs2191349 | DGKB-TMEM195 | T | G | 0.53 | 15 | 52,241 | −0.0024 (−0.0057, 0.0009) | 0.14 | 31 (0, 63) |
| rs340874 | PROX1 | C | T | 0.53 | 14 | 51,449 | −0.0004 (−0.0037, 0.0029) | 0.81 | 12 (0, 50) |
| rs4506565 | TCF7L2 | T | A | 0.29 | 13 | 49,253 | −0.0001 (−0.0038, 0.0036) | 0.97 | 54 (14, 75) |
| rs4607517 | GCK | A | G | 0.17 | 15 | 52,470 | 0.0020 (−0.0023, 0.0063) | 0.35 | 0 (0, 22) |
| rs560887 | G6PC2 | C | T | 0.71 | 15 | 51,479 | 0.0026 (−0.0009, 0.0061) | 0.15 | 0 (0, 28) |
| rs7034200 | GLIS3 | A | C | 0.48 | 15 | 52,016 | 0.0026 (−0.0007, 0.0059) | 0.11 | 5 (0, 56) |
| rs780094 | GCKR | C | T | 0.39 | 15 | 52,442 | 0.0005 (−0.0028, 0.0038) | 0.74 | 41 (0, 68) |
| rs7944584 | MADD | A | T | 0.73 | 15 | 51,263 | 0.0017 (−0.0020, 0.0054) | 0.36 | 46 (2, 71) |
| Magnesium-related SNPs | |||||||||
| rs11144134 | TRPM6 | T | C | 0.92 | 10 | 29,978 | −0.0015 (−0.0091, 0.0061) | 0.70 | 41 (0, 72) |
| rs2274924 | TRPM6 | A | G | 0.84 | 10 | 29,280 | 0.0042 (−0.0013, 0.0097) | 0.12 | 0 (0, 46) |
| rs3740393 | CNNM2 | G | C | 0.85 | 11 | 30,904 | 0.0064 (0.0009, 0.0119) | 0.02 | 38 (0, 70) |
| rs3750425 | TRPM6 | G | A | 0.91 | 10 | 29,978 | 0.0052 (−0.0017, 0.0121) | 0.14 | 0 (0, 2) |
| rs4072037 | MUC1 | C | T | 0.45 | 11 | 30,905 | −0.0028 (−0.0069, 0.0013) | 0.17 | 31 (0, 66) |
| rs6746896 | CNNM4 | A | G | 0.67 | 11 | 30,210 | −0.0001 (−0.0042, 0.0040) | 0.95 | 16 (0, 56) |
| rs8042919 | TRPM7 | G | A | 0.90 | 11 | 30,905 | −0.0049 (−0.0116, 0.0018) | 0.15 | 4 (0, 62) |
| rs994430 | CNNM3 | A | T | 0.60 | 11 | 30,905 | −0.0004 (−0.0043, 0.0035) | 0.84 | 0 (0, 54) |
| Insulin-related SNPs | Outcome is fasting insulin (ln-pmol/L) |
||||||||
| rs35767 | IGF1 | G | A | 0.84 | 15 | 37,485 | 0.0031 (−0.0020, 0.0082) | 0.22 | 21 (0, 57) |
| rs780094 | GCKR | C | T | 0.58 | 15 | 37,804 | −0.0028 (−0.0063, 0.0007) | 0.12 | 36 (0, 66) |
| Magnesium-related SNPs | |||||||||
| rs11144134 | TRPM6 | T | C | 0.92 | 10 | 29,549 | −0.0004 (−0.0080, 0.0072) | 0.94 | 6 (0, 65) |
| rs2274924 | TRPM6 | A | G | 0.83 | 10 | 28,851 | 0.0041 (−0.0012, 0.0094) | 0.13 | 0 (0, 60) |
| rs3740393 | CNNM2 | G | C | 0.85 | 11 | 30,467 | 0.0013 (−0.0042, 0.0068) | 0.64 | 0 (0, 49) |
| rs3750425 | TRPM6 | G | A | 0.91 | 10 | 29,549 | 0.0046 (−0.0021, 0.0113) | 0.17 | 0 (0, 58) |
| rs4072037 | MUC1 | C | T | 0.45 | 11 | 30,468 | −0.0003 (−0.0044, 0.0038) | 0.88 | 27 (0, 64) |
| rs6746896 | CNNM4 | A | G | 0.68 | 11 | 29,773 | 0.0009 (−0.0030, 0.0048) | 0.65 | 6 (0, 63) |
| rs8042919 | TRPM7 | G | A | 0.90 | 11 | 30,468 | −0.0004 (−0.0071, 0.0063) | 0.91 | 0 (0, 58) |
| rs994430 | CNNM3 | A | T | 0.61 | 11 | 30,468 | 0.0004 (−0.0035, 0.0043) | 0.84 | 7 (0, 63) |
Additive allele model, adjusted for age, sex, total energy intake, study center (in Atherosclerosis Risk in Communities Study; Cardiovascular Health Study; Family Heart Study; Health, Aging, and Body Composition Study; Invecchiare in Chianti; Multi-Ethnic Study of Atherosclerosis), and family or population substructure (in Cardiovascular Health Study, Family Heart Study, Framingham Heart Study, Multi-Ethnic Study of Atherosclerosis, Cardiovascular Risk in Young Finns Study). SNP, single nucleotide polymorphism.
Interaction coefficient and 95% shown as β (95% CI).
The number of independent observations in each interaction analysis.