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. 2013 Jul 16;8(7):e68548. doi: 10.1371/journal.pone.0068548

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© 2013 Loots et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Top 20 predicted SMEs were examined for the presence of Mef2 and MyoD clusters. We found clusters of >2 Mef2/MyoD sites over regions >200 bp in all 6 SMEs shown to drive muscle expression in combination with γ-cry promoter (red) and 1/3 of the additional 3 enhancers that were found to drive muscle expression in combination with krt8 promoter only (orange). Two of the negative elements also displayed this cluster (SME6/SME20), but none of the enhancers found to express in tissues other than muscle (green).