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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: J Surg Res. 2013 Feb 24;183(2):767–776. doi: 10.1016/j.jss.2013.02.003

Figure 1.

Figure 1

Mice challenged with combined cutaneous burn and infection with PAO1 had significantly greater weight loss compared with mice not burned, with or without PAO1 challenge (Figure 1a, mean +/− SEM, *P<0.01). Weight loss was maximal at 48 hours after challenge. Skin tissue myeloperoxidase content, reflecting neutrophil accumulation, steadily increased in mice challenged with burn and PAO1, peaking by 48 hours (Figure 1b, mean +/− SEM). Mice without thermal injury but challenged with PAO1 did not have increased MPO content in the skin through 72 hours, indicating that there was no significant neutrophil recruitment to the wound without thermal injury. *P<0.001. Burden of bacterial infection was significantly greater at the skin wound and inoculation site, but consistently had spread to both the lungs and spleen by 72 hours after inoculation (Figure 1c, mean +/− 95% CI).