. Author manuscript; available in PMC: 2014 Jul 1.

Published in final edited form as: Neurotoxicol Teratol. 2013 Apr 24;38:36–45. doi: 10.1016/j.ntt.2013.04.004

Table 1.

Blood and brain Mn concentrations in male littermates of the study animals (PND 24, 66), and in the study subjects at the completion of behavioral testing (~PND 400).

Treatment	PND 24		PND 66		PND ~400
Treatment	Blood Mn^*	Brain Mn	Blood Mn	Brain Mn	Blood Mn	Brain Mn
Control	23.6 ± 1.04^a^#	4.28 ± 0.47^a	9.71 ± 0.447^a	2.14 ± 0.019^a	5.81± 0.342^a	2.06 ± 0.052^a,b
Early 25 mg/kg/d	186 ± 36.8^b	11.5 ± 1.59^b	11.3 ± 0.823^a,b	2.30 ± 0.072^a	7.26 ± 0.614^a	2.00 ± 0.063^a
Early 50 mg/kg/d	267 ± 30.0^c	13.4 ± 1.98^b	15.4 ± 1.12^b	2.28 ± 0.058^a	6.65 0.487^a	1.91 ± 0.022^a
Lifelong 25 mg/kg/d	NA	NA	14.6 ± 1.05^b	2.36 ± 0.039^a,b	9.69 ± 0.442^b	2.28 ± 0.082^b,c
Lifelong 50 mg/kg/d	NA	NA	20.4 ± 1.53^c	2.58 ± 0.077^b	13.7 ± 1.25^c	2.54 ± 0.120^c

Blood Mn in ng/mL, brain Mn in μg/g dry weight.

Data are expressed as means ± SE (n=6 – 11/group). Within a developmental period and type of tissue, treatment groups with different superscripts are statistically different from one another, based on Tukey’s posthoc test on log transformed data.