Figure 1. Model indicating that replication fork stalling in pericentromeric heterochromatin can lead to replication fork breakdown or disassociation of the Rik1-associated replisome (not shown) in brc1Δ cells, leading to defects in propagation of H3K9me2-marked chromatin.²⁸ Note that homology directed repair of the collapsed replication fork results in formation of a Holliday junction.