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. 2013 May 8;12(11):1722–1731. doi: 10.4161/cc.24805

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graphic file with name cc-12-1722-g3.jpg — Figure 3. Disease manifestation in p53^+/R172H mice. Significant splenomegaly (A) and hepatomegaly (B) were most pronounced in p53^+/R172H mice with PML. Hematological disruption in p53^+/R172H mice manifested as anemia (C), elevated MCV (D) and elevated white blood cell levels (E) were most pronounced in p53^+/R172H mice with PML but only in subpopulations of p53^+/R172H mice with reduced PML. Immunophenotyping of lymphocytes from terminally resected tumors of p53^+/R172H mice identified B cell lymphomas to be most abundant in p53^+/R172H mice with PML (F).